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[(Medical )-150(practitioners )-150(need )-150(to )-150(car)18(efully )-150(assess )-150(and )-150(monitor )-150(the )-150(patient\222)111(s )-150(degr)18(ee )-150(of )-150(osteopor)18(osis )-150(and )-150(their )]TJ
0 -1.143 TD
[(fractur)18(e )-81(risk )-81(based )-81(on )-81(the )-81(history )-81(of )-81(bone )-81(mineral )-81(density )-81(and )-81(radiographic )-81(demonstration )-81(of )-81(any )-81(fractur)18(es. )]TJ
0 -1.143 TD
[(As )-23(with )-23(all )-23(pr)18(escribing, )-23(patients )-23(need )-23(to )-23(be )-23(advised )-23(of )-23(potential )-23(side )-23(ef)18(fects )-23(including )-23(the )-23(possibility )-23(of )-23(ONJ. )]TJ
0 -1.143 TD
[(Clearly )54(in )54(patients )54(with )54(sever)18(e )54(osteopor)18(osis )54(and )54(pr)18(e-existing )54(fractur)18(es, )54(for )54(whom )54(the )54(risk )54(of )54(debility )54(fr)18(om )54(further )]TJ
T*
[(fractur)18(es is considerably higher than the risk of ONJ, the bene\037t/risk ratio\
str)18(ongly favours tr)18(eatment.)]TJ
0 -4.517 TD
[(M)10(e)10(d)10(i)10(c)10(a)10(l)10( )-108(p)10(r)10(a)10(c)10(t)10(i)10(t)10(i)10(o)10(n)10(e)10(r)10(s)10( )-108(s)10(h)10(o)10(u)10(l)10(d)10( )-108(a)10(d)10(v)10(i)10(s)10(e)10( )-108(t)10(h)10(e)10(i)10(r)10( )-108(p)10(a)10(t)10(i)10(e)10(n)10(t)10(s)10( )-108(t)10(o)10( )-108(s)10(e)10(e)10( )-108(a)10( )-108(d)10(e)10(n)10(t)10(i)10(s)10(t)10( )-108(f)10(o)10(r)10( )-108(o)10(r)10(a)10(l)10( )-108(e)10(v)10(a)10(l)10(u)10(a)10(t)10(i)10(o)10(n)10( )-108(p)10(r)10(i)10(o)10(r)10( )-108(t)10(o)10( )-108(o)10(r)10( )-108(s)10(h)10(o)10(r)10(t)10(l)10(y)10( )-108(a)10(f)10(t)10(e)10(r )]TJ
0 -1.143 TD
[(c)10(o)10(m)10(m)10(e)10(n)10(c)10(e)10(m)10(e)10(n)10(t)10( )86(o)10(f)10( )86(o)10(r)10(a)10(l)10( )86(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10(s)10(.)10( )86(I)10(f)10( )86(c)10(o)10(s)10(t)10( )86(i)10(s)10( )86(r)10(a)10(i)10(s)10(e)10(d)10( )86(a)10(s)10( )86(a)10(n)10( )86(i)10(s)10(s)10(u)10(e)10( )86(t)10(h)10(e)10(n)10( )86(t)10(h)10(e)10(y)10( )86(c)10(a)10(n)10( )86(b)10(e)10( )86(r)28(e)10(f)10(e)10(r)10(r)28(e)10(d)10( )86(u)10(n)10(d)10(e)10(r)10( )86(t)10(h)10(e)10( )86(M)10(e)10(d)10(i)10(c)10(a)10(r)28(e )]TJ
0 -1.143 TD
[(E)10(P)10(C)10( )10(S)10(c)10(h)10(e)10(m)10(e)10( )10(o)10(r)10( )10(a)10(n)10(y)10( )10(f)10(u)10(t)10(u)10(r)28(e)10( )10(s)10(u)10(c)10(h)10( )10(s)10(c)10(h)10(e)10(m)10(e)10(s)10( )10(t)10(h)10(e)10( )10(G)10(o)10(v)10(e)10(r)-8(n)10(m)10(e)10(n)10(t)10( )10(m)10(a)10(y)10( )10(i)10(n)10(t)10(r)28(o)10(d)10(u)10(c)10(e)10( )10(f)10(o)10(r)10( )10(c)10(h)10(r)28(o)10(n)10(i)10(c)10(a)10(l)10(l)10(y)10( )10(m)10(e)10(d)10(i)10(c)10(a)10(l)10(l)10(y)10( )10(i)10(l)10(l)10( )10(p)10(a)10(t)10(i)10(e)10(n)10(t)10(s)10(.)]TJ
0 -1.953 TD
[(D)10(e)10(n)10(t)10(i)10(s)10(t)10(s)10( )-106(o)10(n)10( )-106(r)28(e)10(c)10(e)10(i)10(p)10(t)10( )-106(o)10(f)10( )-106(r)28(e)10(f)10(e)10(r)10(r)10(a)10(l)10( )-106(f)10(o)10(r)10( )-106(a)10(n)10( )-106(o)10(r)10(a)10(l)10( )-106(h)10(e)10(a)10(l)10(t)10(h)10( )-106(a)10(s)10(s)10(e)10(s)10(s)10(m)10(e)10(n)10(t)10( )-106(p)10(r)10(i)10(o)10(r)10( )-106(t)10(o)10( )-106(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10( )-106(c)10(o)10(m)10(m)10(e)10(n)10(c)10(e)10(m)10(e)10(n)10(t)10( )-106(s)10(h)10(o)10(u)10(l)10(d )]TJ
0 -1.143 TD
[(c)10(o)10(m)10(p)10(l)10(e)10(t)10(e)10(l)10(y)10( )8(e)10(v)10(a)10(l)10(u)10(a)10(t)10(e)10( )8(t)10(h)10(e)10( )9(p)10(a)10(t)10(i)10(e)10(n)10(t)10(\222)121(s)10( )8(t)10(e)10(e)10(t)10(h)10(,)10( )8(c)10(l)10(i)10(n)10(i)10(c)10(a)10(l)10(l)10(y)10( )8(a)10(n)10(d)10( )8(r)10(a)10(d)10(i)10(o)10(g)10(r)10(a)10(p)10(h)10(i)10(c)10(a)10(l)10(l)10(y)10( )9(t)10(o)10( )9(d)10(e)10(t)10(e)10(r)-8(m)10(i)10(n)10(e)10( )9(t)10(h)10(e)10( )8(l)10(i)10(k)10(e)10(l)10(i)10(h)10(o)10(o)10(d)10( )9(o)10(f)10( )9(t)10(h)10(e)10( )8(p)10(a)10(t)10(i)10(e)10(n)10(t )]TJ
T*
[(r)28(e)10(q)10(u)10(i)10(r)10(i)10(n)10(g)10( )-11(e)10(x)10(t)10(r)10(a)10(c)10(t)10(i)10(o)10(n)10(s)10( )-11(o)10(r)10( )-11(o)10(t)10(h)10(e)10(r)10( )-11(b)10(o)10(n)10(e)10( )-11(i)10(n)10(v)10(a)10(s)10(i)10(v)10(e)10( )-11(p)10(r)28(o)10(c)10(e)10(d)10(u)10(r)28(e)10(s)10(.)10( )-11(I)10(t)10( )-11(i)10(s)10( )-11(i)10(m)10(p)10(o)10(r)10(t)10(a)10(n)10(t)10( )-11(t)10(o)10( )-11(d)10(e)10(t)10(e)10(c)10(t)10( )-11(a)10(n)10(d)10( )-11(t)10(r)28(e)10(a)10(t)10( )-11(p)10(e)10(r)10(i)10(o)10(d)10(o)10(n)10(t)10(a)10(l)10( )-11(d)10(i)10(s)10(e)10(a)10(s)10(e)10(. )]TJ
T*
[(I)10(t)10( )-118(w)10(a)10(s)10( )-118(p)10(r)28(e)10(v)10(i)10(o)10(u)10(s)10(l)10(y)10( )-118(t)10(h)10(o)10(u)10(g)10(h)10(t)10( )-119(t)10(h)10(a)10(t)10( )-118(t)10(h)10(e)10(r)28(e)10( )-118(w)10(a)10(s)10( )-118(a)10( )-118(s)10(a)10(f)10(e)10( )-118(w)10(i)10(n)10(d)10(o)10(w)10( )-118(p)10(e)10(r)10(i)10(o)10(d)10( )-118(o)10(f)10( )-118(u)10(p)10( )-118(t)10(o)10( )-118(\037)10(v)10(e)10( )-119(y)10(e)10(a)10(r)10(s)10( )-118(a)10(f)10(t)10(e)10(r)10( )-118(t)10(h)10(e)10( )-118(c)10(o)10(m)10(m)10(e)10(n)10(c)10(e)10(m)10(e)10(n)10(t )]TJ
0 -1.143 TD
[(o)10(f)10( )-122(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10(s)10( )-123(w)10(h)10(e)10(r)28(e)10( )-123(O)10(N)10(J)10( )-122(d)10(i)10(d)10( )-122(n)10(o)10(t)10( )-122(o)10(c)10(c)10(u)10(r)102(.)10( )-122(H)10(o)10(w)10(e)10(v)10(e)10(r)102(,)10( )-122(r)28(e)10(c)10(e)10(n)10(t)10( )-122(s)10(t)10(u)10(d)10(i)10(e)10(s)10( )-123(s)10(h)10(o)10(w)10( )-122(t)10(h)10(a)10(t)10( )-122(u)10(p)10( )-122(t)10(o)10( )-122(2)10(5)10(%)10( )-122(o)10(f)10( )-122(a)10(l)10(l)10( )-122(c)10(a)10(s)10(e)10(s)10( )-123(o)10(f )]TJ
0 -1.143 TD
[(O)10(N)10(J)10( )-29(o)10(c)10(c)10(u)10(r)10( )-29(b)10(e)10(f)10(o)10(r)28(e)10( )-29(t)10(h)10(r)28(e)10(e)10( )-29(y)10(e)10(a)10(r)10(s)10(.)10( )-29(T)10(h)10(u)10(s)10( )-29(w)10(i)10(n)10(d)10(o)10(w)10( )-29(p)10(e)10(r)10(i)10(o)10(d)10(s)10( )-29(a)10(r)28(e)10( )-29(o)10(f)10( )-29(d)10(o)10(u)10(b)10(t)10(f)10(u)10(l)10( )-29(v)10(a)10(l)10(u)10(e)10(.)10( )-29(I)10(f)10( )-29(t)10(h)10(e)10( )-29(p)10(a)10(t)10(i)10(e)10(n)10(t)10(\222)121(s)10( )-29(d)10(e)10(n)10(t)10(a)10(l)10( )-29(c)10(o)10(n)10(d)10(i)10(t)10(i)10(o)10(n)10( )-29(c)10(a)10(n )]TJ
T*
[(b)10(e)10( )-75(r)28(e)10(a)10(s)10(o)10(n)10(a)10(b)10(l)10(y)10( )-75(r)28(e)10(l)10(i)10(a)10(b)10(l)10(y)10( )-75(i)10(m)10(p)10(r)28(o)10(v)10(e)10(d)10( )-75(w)10(i)10(t)10(h)10( )-75(c)10(o)10(n)10(s)10(e)10(r)10(v)10(a)10(t)10(i)10(v)10(e)10( )-75(d)10(e)10(n)10(t)10(a)10(l)10( )-75(t)10(r)28(e)10(a)10(t)10(m)10(e)10(n)10(t)10( )-75(t)10(h)10(e)10(n)10( )-75(t)10(h)10(i)10(s)10( )-75(s)10(h)10(o)10(u)10(l)10(d)10( )-75(b)10(e)10( )-75(d)10(o)10(n)10(e)10(.)10( )-75(I)10(f)10( )-75(h)10(o)10(w)10(e)10(v)10(e)10(r)10( )-75(t)10(h)10(i)10(s )]TJ
0 -1.143 TD
[(c)10(o)10(n)10(s)10(e)10(r)10(v)10(a)10(t)10(i)10(v)10(e)10( )-2(t)10(r)28(e)10(a)10(t)10(m)10(e)10(n)10(t)10( )-1(i)10(s)10( )-1(m)10(e)10(r)28(e)10(l)10(y)10( )-1(g)10(o)10(i)10(n)10(g)10( )-2(t)10(o)10( )-1(d)10(e)10(l)10(a)10(y)10( )-1(i)10(n)10(e)10(v)10(i)10(t)10(a)10(b)10(l)10(e)10( )-1(e)10(x)10(t)10(r)10(a)10(c)10(t)10(i)10(o)10(n)10(s)10( )-1(t)10(h)10(e)10(n)10( )-2(i)10(t)10( )-2(i)10(s)10( )-1(b)10(e)10(s)10(t)10( )-1(t)10(o)10( )-1(p)10(r)28(o)10(c)10(e)10(e)10(d)10( )-2(t)10(o)10( )-2(e)10(x)10(t)10(r)10(a)10(c)10(t)10(i)10(o)10(n)10( )-1(a)10(s )]TJ
0 -1.143 TD
[(e)10(a)10(r)10(l)10(y)10( )10(a)10(s)10( )10(p)10(o)10(s)10(s)10(i)10(b)10(l)10(e)10(,)10( )10(t)10(o)10( )10(d)10(e)10(c)10(r)28(e)10(a)10(s)10(e)10( )10(t)10(h)10(e)10( )10(r)10(i)10(s)10(k)10( )10(o)10(f)10( )10(d)10(e)10(v)10(e)10(l)10(o)10(p)10(i)10(n)10(g)10( )10(O)10(N)10(J)10(.)]TJ
0 -1.953 TD
[(P)10(a)10(t)10(i)10(e)10(n)10(t)10(s)10( )-104(w)10(i)10(t)10(h)10( )-104(d)10(e)10(n)10(t)10(u)10(r)28(e)10(s)10( )-104(n)10(e)10(e)10(d)10( )-104(t)10(h)10(e)10(s)10(e)10( )-104(t)10(o)10( )-104(b)10(e)10( )-104(c)10(a)10(r)28(e)10(f)10(u)10(l)10(l)10(y)10( )-104(c)10(h)10(e)10(c)10(k)10(e)10(d)10( )-104(a)10(n)10(d)10( )-104(e)10(i)10(t)10(h)10(e)10(r)10( )-104(r)28(e)10(m)10(a)10(d)10(e)10( )-104(o)10(r)10( )-104(r)28(e)10(l)10(i)10(n)10(e)10(d)10( )-104(a)10(s)10( )-104(n)10(e)10(e)10(d)10(e)10(d)10(.)10( )-104(P)10(a)10(t)10(i)10(e)10(n)10(t)10(s )]TJ
0 -1.143 TD
[(o)10(n)10( )-192(l)10(o)10(n)10(g)10(-)10(t)10(e)10(r)-8(m)10( )-192(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10( )-192(t)10(h)10(e)10(r)10(a)10(p)10(y)10( )-192(n)10(e)10(e)10(d)10( )-192(r)28(e)10(g)10(u)10(l)10(a)10(r)10( )-192(d)10(e)10(n)10(t)10(a)10(l)10( )-192(m)10(o)10(n)10(i)10(t)10(o)10(r)10(i)10(n)10(g)10(.)10( )-192(I)10(f)10( )-192(t)10(h)10(e)10(i)10(r)10( )-192(t)10(e)10(e)10(t)10(h)10( )-192(b)10(e)10(c)10(o)10(m)10(e)10( )-192(s)10(y)10(m)10(p)10(t)10(o)10(m)10(a)10(t)10(i)10(c )]TJ
0 -1.143 TD
[(a)10(n)10(d)10( )-125(i)10(t)10( )-125(i)10(s)10( )-125(p)10(o)10(s)10(s)10(i)10(b)10(l)10(e)10( )-125(t)10(o)10( )-125(t)10(r)28(e)10(a)10(t)10( )-125(t)10(h)10(e)10( )-125(t)10(o)10(o)10(t)10(h)10( )-125(e)10(n)10(d)10(o)10(d)10(o)10(n)10(t)10(i)10(c)10(a)10(l)10(l)10(y)10( )-125(r)10(a)10(t)10(h)10(e)10(r)10( )-125(t)10(h)10(a)10(n)10( )-125(e)10(x)10(t)10(r)10(a)10(c)10(t)10( )-125(i)10(t)10(,)10( )-125(t)10(h)10(e)10(n)10( )-125(e)10(n)10(d)10(o)10(d)10(o)10(n)10(t)10(i)10(c)10(s)10( )-125(i)10(s)10( )-125(p)10(r)28(e)10(f)10(e)10(r)10(r)28(e)10(d)10(.)10( )-125(F)10(o)10(r )]TJ
0 -1.143 TD
[(p)10(a)10(t)10(i)10(e)10(n)10(t)10(s)10( )43(w)10(i)10(t)10(h)10( )43(d)10(e)10(n)10(t)10(a)10(l)10( )43(i)10(m)10(p)10(l)10(a)10(n)10(t)10(s)10(,)10( )43(t)10(h)10(e)10(s)10(e)10( )43(n)10(e)10(e)10(d)10( )43(t)10(o)10( )43(b)10(e)10( )43(c)10(a)10(r)28(e)10(f)10(u)10(l)10(l)10(y)10( )43(m)10(a)10(i)10(n)10(t)10(a)10(i)10(n)10(e)10(d)10(,)10( )43(a)10(s)10( )43(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10( )43(a)10(s)10(s)10(o)10(c)10(i)10(a)10(t)10(e)10(d)10( )43(r)10(i)10(s)10(k)10( )43(o)10(f)10( )43(l)10(o)10(s)10(s)10( )43(o)10(f )]TJ
T*
[(o)10(s)10(s)10(e)10(o)10(i)10(n)10(t)10(e)10(g)10(r)10(a)10(t)10(i)10(o)10(n)10( )10(o)10(f)10( )10(t)10(h)10(e)10( )10(i)10(m)10(p)10(l)10(a)10(n)10(t)10( )10(h)10(a)10(s)10( )10(b)10(e)10(e)10(n)10( )10(r)28(e)10(p)10(o)10(r)10(t)10(e)10(d)10( )10(t)10(o)10( )10(b)10(e)10( )10(a)10(p)10(p)10(r)28(o)10(x)10(i)10(m)10(a)10(t)10(e)10(l)10(y)10( )10(1)10(%)10(.)]TJ
0 -1.953 TD
[(A)10( )30(b)10(a)10(l)10(a)10(n)10(c)10(e)10(d)10( )30(a)10(n)10(d)10( )30(i)10(n)10(f)10(o)10(r)-8(m)10(e)10(d)10( )30(e)10(x)10(p)10(l)10(a)10(n)10(a)10(t)10(i)10(o)10(n)10( )30(o)10(f)10( )30(t)10(h)10(e)10( )30(r)10(i)10(s)10(k)10( )30(o)10(f)10( )30(O)10(N)10(J)10( )30(n)10(e)10(e)10(d)10(s)10( )30(t)10(o)10( )30(b)10(e)10( )30(g)10(i)10(v)10(e)10(n)10( )30(t)10(o)10( )30(p)10(a)10(t)10(i)10(e)10(n)10(t)10(s)10( )30(w)10(h)10(o)10( )30(r)28(e)10(q)10(u)10(i)10(r)28(e)10( )30(a)10(n)10( )30(e)10(x)10(t)10(r)10(a)10(c)10(t)10(i)10(o)10(n )]TJ
0 -1.143 TD
[(a)10(n)10(d)10( )-72(w)10(h)10(o)10( )-72(a)10(r)28(e)10( )-72(o)10(n)10( )-72(a)10(n)10( )-72(o)10(r)10(a)10(l)10( )-72(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10( )-72(t)10(o)10( )-72(o)10(b)10(t)10(a)10(i)10(n)10( )-72(t)10(h)10(e)10(i)10(r)10( )-72(c)10(o)10(n)10(s)10(e)10(n)10(t)10( )-72(f)10(o)10(r)10( )-72(t)10(h)10(e)10( )-72(p)10(r)28(o)10(c)10(e)10(d)10(u)10(r)28(e)10(.)10( )-72(A)10( )-72(f)10(a)10(s)10(t)10(i)10(n)10(g)10( )-72(s)10(e)10(r)10(u)10(m)10( )-72(b)10(e)10(t)10(a)10(-)10(C)10(T)10(X )]TJ
T*
[(t)10(e)10(s)10(t)10( )-75(m)10(a)10(y)10( )-75(b)10(e)10( )-75(p)10(e)10(r)10(f)10(o)10(r)-8(m)10(e)10(d)10( )-75(t)10(o)10( )-75(d)10(e)10(t)10(e)10(r)-8(m)10(i)10(n)10(e)10( )-75(t)10(h)10(e)10( )-75(d)10(e)10(g)10(r)28(e)10(e)10( )-75(o)10(f)10( )-75(b)10(o)10(n)10(e)10( )-75(t)10(u)10(r)-8(n)10(o)10(v)10(e)10(r)10( )-75(s)10(u)10(p)10(p)10(r)28(e)10(s)10(s)10(i)10(o)10(n)10(.)10( )-75(G)10(e)10(n)10(e)10(r)10(a)10(l)10(l)10(y)102(,)10( )-75(t)10(h)10(e)10( )-75(l)10(e)10(v)10(e)10(l)10( )-75(i)10(n)10(c)10(r)28(e)10(a)10(s)10(e)10(s )]TJ
T*
[(a)10(t)10( )-4(a)10(p)10(p)10(r)28(o)10(x)10(i)10(m)10(a)10(t)10(e)10(l)10(y)10( )-4(2)10(5)10(p)10(g)10(/)10(m)10(o)10(n)10(t)10(h)10( )-4(a)10(f)10(t)10(e)10(r)10( )-4(c)10(e)10(s)10(s)10(a)10(t)10(i)10(o)10(n)10( )-4(o)10(f)10( )-4(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10( )-4(s)10(o)10( )-4(t)10(h)10(i)10(s)10( )-4(c)10(o)10(u)10(l)10(d)10( )-4(b)10(e)10( )-4(r)28(e)10(c)10(h)10(e)10(c)10(k)10(e)10(d)10( )-4(p)10(r)10(i)10(o)10(r)10( )-4(t)10(o)10( )-4(e)10(x)10(t)10(r)10(a)10(c)10(t)10(i)10(o)10(n)10(. )]TJ
0 -1.143 TD
[(T)10(h)10(e)10(r)10(a)10(p)10(e)10(u)10(t)10(i)10(c)10( )10(G)10(u)10(i)10(d)10(e)10(l)10(i)10(n)10(e)10(s)10( )10(r)28(e)10(c)10(o)10(m)10(m)10(e)10(n)10(d)10( )10(a)10( )10(p)10(r)28(o)10(p)10(h)10(y)10(l)10(a)10(c)10(t)10(i)10(c)10( )10(d)10(o)10(s)10(e)10( )10(o)10(f)10( )10(2)10(g)10( )10(a)10(m)10(o)10(x)10(i)10(c)10(i)10(l)10(l)10(i)10(n)10( )10(o)10(n)10(e)10( )10(h)10(o)10(u)10(r)10( )10(p)10(r)10(i)10(o)10(r)10( )10(t)10(o)10( )10(t)10(h)10(e)10( )10(e)10(x)10(t)10(r)10(a)10(c)10(t)10(i)10(o)10(n)10(.)]TJ
0 -1.953 TD
[(T)121(e)10(e)10(t)10(h)10( )-70(s)10(h)10(o)10(u)10(l)10(d)10( )-70(b)10(e)10( )-70(e)10(x)10(t)10(r)10(a)10(c)10(t)10(e)10(d)10( )-70(w)10(i)10(t)10(h)10( )-70(t)10(h)10(e)10( )-70(m)10(i)10(n)10(i)10(m)10(u)10(m)10( )-70(o)10(f)10( )-70(t)10(r)10(a)10(u)10(m)10(a)10(,)10( )-70(a)10(n)10(y)10( )-70(e)10(x)10(p)10(o)10(s)10(e)10(d)10( )-70(b)10(o)10(n)10(e)10( )-70(c)10(a)10(r)28(e)10(f)10(u)10(l)10(l)10(y)10( )-70(r)28(e)10(m)10(o)10(v)10(e)10(d)10( )-70(a)10(n)10(d)10( )-70(t)10(h)10(e)10( )-70(s)10(o)10(c)10(k)10(e)10(t )]TJ
0 -1.143 TD
[(s)10(u)10(t)10(u)10(r)28(e)10(d)10(.)10( )-8(O)10(r)10(a)10(l)10( )-8(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10(s)10( )-8(c)10(a)10(n)10( )-8(b)10(e)10( )-8(c)10(o)10(m)10(m)10(e)10(n)10(c)10(e)10(d)10( )-8(a)10(t)10( )-8(a)10(p)10(p)10(r)28(o)10(x)10(i)10(m)10(a)10(t)10(e)10(l)10(y)10( )-8(t)10(h)10(r)28(e)10(e)10( )-8(t)10(o)10( )-8(f)10(o)10(u)10(r)10( )-8(w)10(e)10(e)10(k)10(s)10( )-8(a)10(f)10(t)10(e)10(r)10( )-8(t)10(h)10(e)10( )-8(e)10(x)10(t)10(r)10(a)10(c)10(t)10(i)10(o)10(n)10( )-8(o)10(r )]TJ
0 -1.143 TD
[(o)10(n)10(c)10(e)10( )10(t)10(h)10(e)10(r)28(e)10( )10(i)10(s)10( )10(p)10(r)10(i)10(m)10(a)10(r)10(y)10( )10(m)10(u)10(c)10(o)10(s)10(a)10(l)10( )10(c)10(o)10(v)10(e)10(r)10(a)10(g)10(e)10( )10(a)10(n)10(d)10( )10(c)10(o)10(m)10(m)10(e)10(n)10(c)10(e)10(m)10(e)10(n)10(t)10( )10(o)10(f)10( )10(s)10(o)10(c)10(k)10(e)10(t)10( )10(h)10(e)10(a)10(l)10(i)10(n)10(g)10(.)]TJ
0.29 0 0.1 0.14 k
/GS0 gs
/T1_1 1 Tf
1.08 -1.683 Td
[(T)10(h)10(e)10( )-75(k)10(e)10(y)10( )-76(s)10(t)10(e)10(p)10( )-76(f)10(o)10(r)10( )-76(a)10(n)10(y)10( )-75(p)10(a)10(t)10(i)10(e)10(n)10(t)10( )-75(w)10(h)10(o)10( )-75(i)10(s)10( )-76(o)10(n)10( )-75(a)10( )-76(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10( )-75(a)10(n)10(d)10( )-76(r)28(e)10(q)10(u)10(i)10(r)28(e)10(s)10( )-75(d)10(e)10(n)10(t)10(a)10(l)10( )-75(t)10(r)28(e)10(a)10(t)10(m)10(e)10(n)10(t)10( )-76(i)10(s)10( )-76(t)10(h)10(a)10(t)10( )-75(t)10(h)10(e )]TJ
0 -1.143 TD
[(p)10(a)10(t)10(i)10(e)10(n)10(t)10(\222)84(s)10( )4(d)10(e)10(n)10(t)10(a)10(l)10( )4(a)10(n)10(d)10( )4(m)10(e)10(d)10(i)10(c)10(a)10(l)10( )4(p)10(r)10(a)10(c)10(t)10(i)10(t)10(i)10(o)10(n)10(e)10(r)10(s)10( )4(s)10(h)10(o)10(u)10(l)10(d)10( )4(l)10(i)10(a)10(i)10(s)10(e)10( )4(t)10(o)10( )4(d)10(e)10(t)10(e)10(r)-8(m)10(i)10(n)10(e)10( )4(t)10(h)10(e)10( )4(o)10(p)10(t)10(i)10(m)10(u)10(m)10( )4(t)10(r)28(e)10(a)10(t)10(m)10(e)10(n)10(t)10( )4(f)10(o)10(r)10( )4(b)10(o)10(t)10(h )]TJ
T*
[(t)10(h)10(e)10( )10(p)10(a)10(t)10(i)10(e)10(n)10(t)10(\222)84(s)10( )10(m)10(o)10(u)10(t)10(h)10( )10(a)10(n)10(d)10( )10(t)10(h)10(e)10(i)10(r)10( )10(b)10(o)10(n)10(e)10(s)10(.)]TJ
0 0 0 1 k
/GS1 gs
/T1_0 1 Tf
-1.08 -4.517 Td
[(R)10(e)10(c)10(e)10(n)10(t)10(l)10(y)102(,)10( )105(i)10(n)10(t)10(r)10(a)10(v)10(e)10(n)10(o)10(u)10(s)10( )105(d)10(o)10(s)10(a)10(g)10(e)10(s)10( )105(o)10(f)10( )105(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10(s)10( )105(h)10(a)10(v)10(e)10( )105(b)10(e)10(e)10(n)10( )105(i)10(n)10(t)10(r)28(o)10(d)10(u)10(c)10(e)10(d)10( )105(f)10(o)10(r)10( )105(o)10(s)10(t)10(e)10(o)10(p)10(o)10(r)28(o)10(s)10(i)10(s)10(.)10( )105(T)10(h)10(e)10(r)28(e)10( )105(a)10(r)28(e)10( )105(c)10(o)10(n)10(s)10(i)10(d)10(e)10(r)10(a)10(b)10(l)10(e )]TJ
T*
[(a)10(d)10(v)10(a)10(n)10(t)10(a)10(g)10(e)10(s)10( )-103(t)10(o)10( )-103(t)10(h)10(e)10( )-103(p)10(a)10(t)10(i)10(e)10(n)10(t)10( )-103(a)10(s)10( )-103(i)10(t)10( )-103(i)10(n)10(v)10(o)10(l)10(v)10(e)10(s)10( )-103(a)10( )-103(s)10(i)10(n)10(g)10(l)10(e)10( )-103(i)10(n)10(f)10(u)10(s)10(i)10(o)10(n)10( )-103(r)10(a)10(t)10(h)10(e)10(r)10( )-103(t)10(h)10(a)10(n)10( )-103(w)10(e)10(e)10(k)10(l)10(y)10( )-103(t)10(a)10(b)10(l)10(e)10(t)10(s)10(.)10( )-103(I)10(t)10( )-103(i)10(s)10( )-103(i)10(m)10(p)10(o)10(r)10(t)10(a)10(n)10(t)10( )-103(t)10(h)10(a)10(t)10( )-103(s)10(u)10(c)10(h )]TJ
T*
[(p)10(a)10(t)10(i)10(e)10(n)10(t)10(s)10( )19(h)10(a)10(v)10(e)10( )19(t)10(h)10(e)10(i)10(r)10( )19(m)10(o)10(u)10(t)10(h)10( )19(c)10(h)10(e)10(c)10(k)10(e)10(d)10( )19(b)10(y)10( )19(a)10( )19(d)10(e)10(n)10(t)10(i)10(s)10(t)10( )19(p)10(r)10(i)10(o)10(r)10( )19(t)10(o)10( )19(t)10(h)10(e)10( )19(i)10(n)10(f)10(u)10(s)10(i)10(o)10(n)10(.)10( )19(B)10(o)10(n)10(e)10( )19(t)10(u)10(r)-8(n)10(o)10(v)10(e)10(r)10( )19(d)10(e)10(c)10(r)28(e)10(a)10(s)10(e)10(s)10( )19(r)10(a)10(p)10(i)10(d)10(l)10(y)10( )19(i)10(n)10( )19(p)10(a)10(t)10(i)10(e)10(n)10(t)10(s )]TJ
0 -1.143 TD
[(o)10(n)10( )-111(I)10(V)10( )-111(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10(s)10( )-111(a)10(n)10(d)10( )-111(r)28(e)10(m)10(a)10(i)10(n)10(s)10( )-111(l)10(o)10(w)10( )-111(f)10(o)10(r)10( )-111(o)10(n)10(e)10( )-111(t)10(o)10( )-111(t)10(w)10(o)10( )-111(y)10(e)10(a)10(r)10(s)10(.)10( )-111(T)10(h)10(u)10(s)10( )-111(d)10(r)10(u)10(g)10( )-111(h)10(o)10(l)10(i)10(d)10(a)10(y)10(s)10( )-111(a)10(r)28(e)10( )-111(m)10(o)10(r)28(e)10( )-111(d)10(i)10(f)10(\037)10(c)10(u)10(l)10(t)10( )-111(a)10(n)10(d)10( )-111(t)10(h)10(e )]TJ
0 -1.143 TD
[(s)10(e)10(c)10(o)10(n)10(d)10( )10(o)10(r)10( )10(s)10(u)10(b)10(s)10(e)10(q)10(u)10(e)10(n)10(t)10( )10(i)10(n)10(f)10(u)10(s)10(i)10(o)10(n)10( )10(s)10(h)10(o)10(u)10(l)10(d)10( )10(b)10(e)10( )10(d)10(e)10(f)10(e)10(r)10(r)28(e)10(d)10( )10(u)10(n)10(t)10(i)10(l)10( )10(a)10(f)10(t)10(e)10(r)10( )10(d)10(e)10(n)10(t)10(a)10(l)10( )10(e)10(x)10(t)10(r)10(a)10(c)10(t)10(i)10(o)10(n)10(.)]TJ
0 -4.517 TD
[(P)10(a)10(t)10(i)10(e)10(n)10(t)10(s)10( )-150(w)10(i)10(t)10(h)10( )-150(e)10(s)10(t)10(a)10(b)10(l)10(i)10(s)10(h)10(e)10(d)10( )-150(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10( )-150(a)10(s)10(s)10(o)10(c)10(i)10(a)10(t)10(e)10(d)10( )-150(O)10(N)10(J)10( )-150(a)10(r)28(e)10( )-150(b)10(e)10(s)10(t)10( )-150(t)10(r)28(e)10(a)10(t)10(e)10(d)10( )-150(b)10(y)10( )-150(s)10(p)10(e)10(c)10(i)10(a)10(l)10(i)10(s)10(t)10( )-150(d)10(e)10(n)10(t)10(i)10(s)10(t)10(s)10( )-150(w)10(o)10(r)10(k)10(i)10(n)10(g)10( )-150(i)10(n )]TJ
0 -1.143 TD
[(a)10(s)10(s)10(o)10(c)10(i)10(a)10(t)10(i)10(o)10(n)10( )-137(w)10(i)10(t)10(h)10( )-137(e)10(i)10(t)10(h)10(e)10(r)10( )-137(t)10(h)10(e)10( )-137(p)10(a)10(t)10(i)10(e)10(n)10(t)10(\222)121(s)10( )-137(m)10(e)10(d)10(i)10(c)10(a)10(l)10( )-137(p)10(r)10(a)10(c)10(t)10(i)10(t)10(i)10(o)10(n)10(e)10(r)10( )-137(o)10(r)10( )-137(a)10( )-137(m)10(e)10(t)10(a)10(b)10(o)10(l)10(i)10(c)10( )-137(b)10(o)10(n)10(e)10( )-137(d)10(i)10(s)10(e)10(a)10(s)10(e)10(s)10( )-137(p)10(h)10(y)10(s)10(i)10(c)10(i)10(a)10(n)10(.)10( )-137(I)10(f)10( )-137(p)10(o)10(s)10(s)10(i)10(b)10(l)10(e )]TJ
T*
[(m)10(e)10(d)10(i)10(c)10(a)10(l)10(l)10(y)102(,)10( )-169(t)10(h)10(e)10( )-169(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10( )-169(s)10(h)10(o)10(u)10(l)10(d)10( )-169(b)10(e)10( )-169(c)10(e)10(a)10(s)10(e)10(d)10( )-169(f)10(o)10(r)10( )-169(a)10( )-169(p)10(r)28(o)10(l)10(o)10(n)10(g)10(e)10(d)10( )-169(p)10(e)10(r)10(i)10(o)10(d)10(.)10( )-169(T)102(r)28(e)10(a)10(t)10(m)10(e)10(n)10(t)10( )-169(o)10(f)10( )-169(e)10(s)10(t)10(a)10(b)10(l)10(i)10(s)10(h)10(e)10(d)10( )-169(O)10(N)10(J)10( )-169(i)10(s )]TJ
T*
[(p)10(r)28(e)10(f)10(e)10(r)10(a)10(b)10(l)10(y)10( )49(n)10(o)10(t)10( )49(a)10(g)10(g)10(r)28(e)10(s)10(s)10(i)10(v)10(e)10( )49(a)10(n)10(d)10( )49(t)10(h)10(e)10( )49(u)10(s)10(e)10( )49(o)10(f)10( )49(0)10(.)10(1)10(2)10(%)10( )49(c)10(l)10(o)10(r)10(h)10(e)10(x)10(i)10(d)10(i)10(n)10(e)10( )49(m)10(o)10(u)10(t)10(h)10(w)10(a)10(s)10(h)10(e)10(s)10( )49(a)10(n)10(d)10( )49(a)10(n)10(t)10(i)10(b)10(i)10(o)10(t)10(i)10(c)10(s)10( )49(f)10(o)10(r)10( )49(s)10(o)10(f)10(t)10( )49(t)10(i)10(s)10(s)10(u)10(e)10( )49(p)10(a)10(i)10(n)10( )49(a)10(n)10(d )]TJ
0 -1.143 TD
[(s)10(w)10(e)10(l)10(l)10(i)10(n)10(g)10( )-39(i)10(s)10( )-39(i)10(n)10(d)10(i)10(c)10(a)10(t)10(e)10(d)10(.)10( )-39(S)10(u)10(r)28(g)10(e)10(r)10(y)10( )-39(s)10(h)10(o)10(u)10(l)10(d)10( )-39(o)10(n)10(l)10(y)10( )-39(b)10(e)10( )-39(p)10(e)10(r)10(f)10(o)10(r)-8(m)10(e)10(d)10( )-39(f)10(o)10(r)10( )-39(t)10(h)10(e)10( )-39(r)28(e)10(m)10(o)10(v)10(a)10(l)10( )-39(o)10(f)10( )-39(l)10(o)10(o)10(s)10(e)10( )-39(s)10(e)10(q)10(u)10(e)10(s)10(t)10(r)10(a)10(e)10( )-39(o)10(r)10( )-39(i)10(n)10( )-39(t)10(h)10(e)10( )-39(e)10(v)10(e)10(n)10(t)10( )-39(o)10(f )]TJ
0 -1.143 TD
[(s)10(e)10(v)10(e)10(r)28(e)10(l)10(y)10( )10(p)10(a)10(i)10(n)10(f)10(u)10(l)10( )10(e)10(n)10(d)10( )10(s)10(t)10(a)10(g)10(e)10( )10(O)10(N)10(J)10(,)10( )10(t)10(h)10(e)10(n)10( )10(j)10(a)10(w)10( )10(r)28(e)10(s)10(e)10(c)10(t)10(i)10(o)10(n)10( )10(c)10(o)10(u)10(l)10(d)10( )10(b)10(e)10( )10(c)10(o)10(n)10(s)10(i)10(d)10(e)10(r)28(e)10(d)10(.)]TJ
0 -4.517 TD
[(I)10(t)10( )-60(s)10(h)10(o)10(u)10(l)10(d)10( )-60(b)10(e)10( )-60(n)10(o)10(t)10(e)10(d)10( )-60(t)10(h)10(a)10(t)10( )-60(O)10(N)10(J)10( )-60(i)10(s)10( )-60(m)10(u)10(c)10(h)10( )-60(m)10(o)10(r)28(e)10( )-60(l)10(i)10(k)10(e)10(l)10(y)10( )-60(t)10(o)10( )-60(o)10(c)10(c)10(u)10(r)10( )-60(i)10(n)10( )-60(c)10(a)10(n)10(c)10(e)10(r)10( )-60(p)10(a)10(t)10(i)10(e)10(n)10(t)10(s)10( )-60(o)10(n)10( )-60(i)10(n)10(t)10(r)10(a)10(v)10(e)10(n)10(o)10(u)10(s)10( )-60(b)10(i)10(s)10(p)10(h)10(o)10(s)10(p)10(h)10(o)10(n)10(a)10(t)10(e)10(s)10(.)]TJ
( )Tj
0 -1.143 TD
[(T)10(h)10(e)10( )-29(r)10(i)10(s)10(k)10( )-29(t)10(h)10(e)10(r)28(e)10( )-29(o)10(f)10( )-29(O)10(N)10(J)10( )-29(f)10(o)10(l)10(l)10(o)10(w)10(i)10(n)10(g)10( )-29(e)10(x)10(t)10(r)10(a)10(c)10(t)10(i)10(o)10(n)10(s)10( )-29(i)10(s)10( )-29(m)10(u)10(c)10(h)10( )-29(h)10(i)10(g)10(h)10(e)10(r)102(,)10( )-29(o)10(f)10( )-29(t)10(h)10(e)10( )-29(o)10(r)28(d)10(e)10(r)10( )-29(o)10(f)10( )-29(1)10( )-29(i)10(n)10( )-29(1)10(0)10( )-29(t)10(o)10( )-29(1)10( )-29(i)10(n)10( )-29(1)10(5)10(.)10( )-29(S)10(u)10(c)10(h)10( )-29(p)10(a)10(t)10(i)10(e)10(n)10(t)10(s)10( )-29(a)10(r)28(e )]TJ
0 -1.143 TD
[(b)10(e)10(s)10(t)10( )10(m)10(a)10(n)10(a)10(g)10(e)10(d)10( )10(b)10(y)10( )10(s)10(p)10(e)10(c)10(i)10(a)10(l)10(i)10(s)10(t)10( )10(o)10(r)10(a)10(l)10( )10(a)10(n)10(d)10( )10(m)10(a)10(x)10(i)10(l)10(l)10(o)10(f)10(a)10(c)10(i)10(a)10(l)10( )10(s)10(u)10(r)28(g)10(e)10(o)10(n)10(s)10( )10(a)10(n)10(d)10( )10(t)10(h)10(e)10( )10(p)10(a)10(t)10(i)10(e)10(n)10(t)10(\222)121(s)10( )10(m)10(e)10(d)10(i)10(c)10(a)10(l)10( )10(o)10(n)10(c)10(o)10(l)10(o)10(g)10(i)10(s)10(t)10(.)]TJ
ET
q
0 0 595.276 841.89 re
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255.827 -22.677 l
260.079 -22.677 260.079 -18.425 v
260.079 -4.252 l
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[(Is )1(ONJ )1(mor)18(e )1(likely )1(to )1(occur )1(in )1(cancer )1(patients?)]TJ
ET
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0 0 595.276 841.89 re
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367.087 -22.677 l
371.339 -22.677 371.339 -18.425 v
371.339 -4.252 l
371.339 0 367.087 0 v
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f
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[(What )7(ar)18(e )7(the )7(risks )7(for )7(patients )7(using )7(intravenous )7(bisphosphonates?)]TJ
ET
q
0 0 595.276 841.89 re
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0 0 m
-4.252 0 -4.252 -4.252 v
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228.189 -22.677 l
232.441 -22.677 232.441 -18.425 v
232.441 -4.252 l
232.441 0 228.189 0 v
h
f
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12 0 0 12 48.289 190.0724 Tm
[(How should established ONJ be tr)18(eated?)]TJ
ET
q
0 0 595.276 841.89 re
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245.197 -22.677 l
249.449 -22.677 249.449 -18.425 v
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249.449 0 245.197 0 v
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12 0 0 12 48.289 791.9385 Tm
[(What can doctors do to try to pr)18(event ONJ?)]TJ
ET
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301.89 -22.677 l
306.142 -22.677 306.142 -18.425 v
306.142 -4.252 l
306.142 0 301.89 0 v
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[(What should you do if a patient r)18(equir)18(es an extraction?)]TJ
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